Guadalajara, which lies about 540 km (335 mi) from Mexico City, is linked to the nation’s capital by highways 15 and 57. Highway 54 connects Guadalajara to Colima and Highway 80 leads to Leon and Guanajuato. The city has a bus station with service from bus lines ETN, Omnibus de Oriente, Flecha Amarilla and Estrella del Pacifico. The following airlines operate out of Guadalajara’s international airport and offer direct flights to Mexico City, Monterrrey, Morelia, Hermosillo, Toluca, Guanajuato, Puerto Vallarta (see flights in Puerto Vallarta) and Tijuana: Mexicana, Aeromexico, Aviacsa, Lineas Aereas Azteca and Magnicharters. Continental and United Airlines have service to numerous cities in the United States.
Aeropuerto Internacional Miguel Hidalgo y Costilla (airport) – Located at Km 17.5 on the Chapala Highway. Tel. (333) 688-6484
Central de Autobuses (bus station) – Located in Tlaquepaque off the modulo 4 exit on the Mexico-Zapotlanejo Highway. Tel. (333) 600-0495 or (333) 600-0066.Source:visitmexico.com